Injectable platelet-rich fibrin for the treatment of periodontal intrabony defects: A systematic review
DOI:
https://doi.org/10.36557/2009-3578.2025v11n2p8129-8145Palabras clave:
Platelet-Rich Fibrin, Periodontal disease, Tissue Regeneration., systematic review, Alveolar bone lossResumen
Bone regeneration in periodontal defects is essential for tooth preservation and alveolar health. Among the materials most frequently used for regenerative procedures is sticky bone, a combination of injectable platelet-rich fibrin (i-PRF) and a bone graft. This combination, widely applied in periodontology, may improve clinical and radiographic parameters; however, solid clinical evidence remains limited. This systematic review aimed to evaluate the current evidence regarding the clinical and radiographic effectiveness of i-PRF as an adjunct in bone regeneration procedures compared with other biomaterials or conventional PRF. Randomized Clinical Trials (RCTs) evaluating the use of i-PRF or sticky bone compared with isolated bone grafts (demineralized freeze-dried bone allograft, hydroxyapatite, and xenografts) or conventional PRF were included. The search was conducted in PubMed/MEDLINE, Scopus, Web of Science, Embase, the Cochrane Library, and additional sources up to October 2025. Risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool. Data synthesis was performed narratively, grouping studies according to intervention type and assessing outcomes. Five studies were included from an initial 646 records, totaling 135 participants. Four of the five studies (80%) demonstrated statistically superior clinical (Probing pocket depth reduction, clinical attachment level gain) and radiographic (bone fill) outcomes for the i-PRF group. One study (20%) found no significant differences between groups. Three studies also reported notable improvements in graft handling (sticky bone formation) when i-PRF was used. Current evidence suggests a potential benefit of i-PRF in optimizing bone regeneration outcomes; however, methodological heterogeneity and the limited number of RCTs constrain the formulation of strong clinical recommendations. This review was registered in the PROSPERO database (International Prospective Register of Systematic Reviews).
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Derechos de autor 2025 Mateus Pacer de Lima, Andre Luis Dias Carvalho, Cesar Augusto Spada, Alana Zenilda Thomaz Sacht, Maysa Mombelli Citadin, Vitoria Bortolon Jassniker, Bárbara Matthes Augsten, Bianca Medeiros Maram, Veridiana Camilotti
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