Advances in adjuvant therapies for peri-implantitis and bone regeneration:

lasers, photodynamic therapy, and platelet concentrates (PRP, PRF, CGF).

Authors

DOI:

https://doi.org/10.36557/2009-3578.2025v11n2p4827-4835

Keywords:

Peri-implantitis, Lasers, Photodynamic Therapy, Platelet-Rich Plasma, Platelet-Rich Fibrin, Concentrated Growth Factor

Abstract

Peri-implantitis remains a major challenge in modern implant dentistry, characterized by inflammation and progressive marginal bone loss. Conventional treatment based on mechanical debridement faces limitations due to implant surface morphology and microbial resilience. Adjunctive therapies such as lasers, antimicrobial photodynamic therapy (aPDT), and autologous platelet concentrates (PRP, PRF, CGF) have been investigated to enhance decontamination and promote tissue regeneration. This review integrates recent evidence on mechanisms of action, clinical outcomes, and innovations, discussing advantages, limitations, and clinical perspectives.

 

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References

DAI, Y. et al. Clinical efficacy of concentrated growth factors combined with mineralized collagen in guided bone regeneration. International Journal of Oral and Maxillofacial Surgery, v. 49, n. 11, p. 1532-1540, 2020.

DERKS, J.; TOMASI, C. Peri-implant health and disease: a systematic review. Journal of Clinical Periodontology, v. 42, supl. 16, p. S158-S171, 2015.

DOHAN EHRENFEST, D. M. et al. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends in Biotechnology, v. 27, n. 3, p. 158-167, 2009.

KIM, T. H. et al. Advanced platelet concentrates: albumin-stabilized PRF and CGF. Materials, v. 15, n. 8, p. 2763-2774, 2022.

LOMBARDO, G. et al. Lasers and photodynamic therapy in peri-implantitis treatment: systematic review. Dentistry Journal, v. 9, n. 11, p. 127, 2021.

MALCANGI, G. et al. Maxillary sinus augmentation using autologous platelet concentrates (PRP, PRF, CGF) combined with bone graft: a systematic review. Cells, v. 12, p. 1797, 2023.

MARX, R. E. et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 85, n. 6, p. 638-646, 1998.

NIZAM, N. et al. The role of leukocyte- and platelet-rich fibrin in sinus augmentation: randomized controlled trial. Clinical Oral Implants Research, v. 28, n. 10, p. 1093-1103, 2017.

NOVAES JR., A. B. et al. New strategies and developments for peri-implant disease: an overview. Brazilian Oral Research, v. 33, supl. 1, p. e071, 2019.

RAHMAN, B. ACHARYA, A.B., SIDDIQUI, R., et al. Photodynamic Therapy for Peri-Implant Diseases. Antibiotics 2022, 11, 918.

TAVARES, L. J. et al. The impact of antimicrobial photodynamic therapy on peri-implant disease: mechanisms. Photodiagnosis and Photodynamic Therapy, v. 17, p. 236-244, 2017.

ZENG, Y. et al. Effectiveness of adjunctive lasers and PDT in peri-implant treatment: Bayesian network meta-analysis. Photodiagnosis and Photodynamic Therapy, v. 40, p. 103106, 2022.

ZEISS Clinical Report. Peri-implantitis treated with Er,Cr:YSGG laser under magnification. Case Report in Dentistry, 2021.

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Published

2025-10-10

How to Cite

de Castro e Silva, A. L., Vaz Moreira , M., Vera Santos Gumert, J., Roberta Nepomuceno Atripoli , C., Caroline Leandro da Conceição , A., Firmo Chaves Silva , J., … Borges de Oliveira, J. C. (2025). Advances in adjuvant therapies for peri-implantitis and bone regeneration: : lasers, photodynamic therapy, and platelet concentrates (PRP, PRF, CGF) . INTERFERENCE: A JOURNAL OF AUDIO CULTURE, 11(2), 4827–4835. https://doi.org/10.36557/2009-3578.2025v11n2p4827-4835

Issue

Vol. 11 No. 2 (2025): IJAC - QUALIS A2

Section

Literature Review

License

Copyright (c) 2025 Ana Luísa de Castro e Silva, Maiana Vaz Moreira , Jennifer Vera Santos Gumert, Camila Roberta Nepomuceno Atripoli , Aléxia Caroline Leandro da Conceição , Jonatas Firmo Chaves Silva , Diego Barbosa da Silva , William Alves dos Reis, Marcos Pereira Villa-Nova, Jéssica Christina Borges de Oliveira

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